COST Action CA18139

Genomics of MusculoSkeletal traits Translational Network

Join the Action

The Action is an open, interdisciplinary and growing network welcoming academics, practitioners and relevant stakeholders to contribute to the activities of the GEMSTONE.

Description

The musculoskeletal system is a key element for healthy aging, being mobility a fundamental component of quality of life, health, and independence of aging individuals.
The unprecedented amount of discoveries arising from genome-wide association studies (GWAS) have set a new era full of translational potential in the field of musculoskeletal biology. Coupled to the growing understanding of monogenetic disorders, the GWAS discoveries have set a roadmap characterizing the biological pathways underlying the musculoskeletal metabolism. The musculoskeletal field is now confronted with new biology arising in the form of novel factors clustering in known molecular pathways but also with novel factors whose role and function remains to be elucidated.

Several opportunities to increase the amount of discoveries like the imminence of whole-genome sequencing efforts, the advent of a new generation of “very-low cost” GWAS arrays and the availability of very large mega GWAS studies like the UKBIOBANK are now in place. The challenge is now about bringing the knowledge arising from high-throughput analysis of increasingly available BIG DATA to a larger set of researchers, who can both contribute to 1) generating additional genetic discoveries and 2) setting the ground for their functional characterization in order to translate these genetic discoveries into meaningful clinical applications. To do this, GEMSTONE will be the mechanism to reach out to a wider range of researchers active in musculoskeletal biology, in order to fuel the production of discoveries and their biological relevance, which will allow their translation to treatments and new molecular definitions.

Latest News

Applications should be submitted at bonesecr@strutture.univaq.it and should include a detailed CV with a complete list of publications and other relevant achievements.Place of Work: University of L’Aquila, Italy, Department of...
We are seeking a highly motivated post-doctoral researcher interested in osteo-immunology to join our team and work on the diversity of osteoclasts, the multinucleated monocytic cells involved in bone resorption.We...
THREE ITC GRANTS are available for PhD students and Young Researchers and Innovators (YRI) that are WG members of GEMSTONE  from COST Inclusiveness Target Countries (ITC) and Near Neighbor Country (NNC)....

Upcoming Events

1 August
2022
WG1-WG4 One-to-one meeting: second stage of data collection
This meeting will involve the WG1 leaders and the leaders of each of the other WGs Meeting agenda: -Describing the support WG1 can provide -Ask for detailed information about the...
Location: Virtual (Netherlands)
1 August
2022
GEMSTONE WG4 (in collaboration with WG2 & WG5) training school: Bone cryo-histomorphometry
Guidelines and detailed methodology for standardized evaluation of bone remodeling (bone formation and resorption) in the femur and/or lumbar vertebra. This hands-on is especially recommended for those who attended the...
Location: Tel Aviv (Israel)
1 September
2022
WG1-WG5 One-to-one meeting: second stage of data collection
This meeting will involve the WG1 leaders and the leaders of each of the other WGs Meeting agenda: -Describing the support WG1 can provide -Ask for detailed information about the...
Location: Virtual (Netherlands)
2 September
2022
GEMSTONE WG2: Muscle phenotyping from basic to clinical research
A hybrid conference organized by WG2 on musculoskeletal phenotyping. This working group is working on their second manuscript, focused more on muscular phenotypes. All working 2 members and YRI (Young...
Location: Lisbon (Portugal)
12 September
2022
GEMSTONE WG4 TS: Osteoblast cell models and functional GWAS hits validation
In vitro cell culturing and osteoblast cell models are an essential step infunctional validation of potential novel GWAS gene targets, as they allowconfirmation of genes’ involvement in bone related processes...
Location: Ljubljana (Slovenia)
21 September
2022
GEMSTONE GP3 Annual meeting
The annual meeting will last two days: the first day will comprise an MC meeting and working group meetings and the second day will be a workshop organized by WG3:...
Location: Rotterdam (Netherlands)