COST Action CA18139

Genomics of MusculoSkeletal traits Translational Network

Join the Action

The Action is an open, interdisciplinary and growing network welcoming academics, practitioners and relevant stakeholders to contribute to the activities of the GEMSTONE.


The musculoskeletal system is a key element for healthy aging, being mobility a fundamental component of quality of life, health, and independence of aging individuals.
The unprecedented amount of discoveries arising from genome-wide association studies (GWAS) have set a new era full of translational potential in the field of musculoskeletal biology. Coupled to the growing understanding of monogenetic disorders, the GWAS discoveries have set a roadmap characterizing the biological pathways underlying the musculoskeletal metabolism. The musculoskeletal field is now confronted with new biology arising in the form of novel factors clustering in known molecular pathways but also with novel factors whose role and function remains to be elucidated.

Several opportunities to increase the amount of discoveries like the imminence of whole-genome sequencing efforts, the advent of a new generation of “very-low cost” GWAS arrays and the availability of very large mega GWAS studies like the UKBIOBANK are now in place. The challenge is now about bringing the knowledge arising from high-throughput analysis of increasingly available BIG DATA to a larger set of researchers, who can both contribute to 1) generating additional genetic discoveries and 2) setting the ground for their functional characterization in order to translate these genetic discoveries into meaningful clinical applications. To do this, GEMSTONE will be the mechanism to reach out to a wider range of researchers active in musculoskeletal biology, in order to fuel the production of discoveries and their biological relevance, which will allow their translation to treatments and new molecular definitions.

Latest News

Above all, let us wish you this message finds you and your beloved in good health during this difficult COVID-19 period. If not, we wish you character and strength to...
GEMSTONE is happy to announce the seven grantee winners of an STSM grant in the first year of our COST action 18139. We are very happy to see the interest...
Gemstone has fellowships for Inclusiveness Target Countries (ITC) researchers to the WORLD CONGRESS ON OSTEOPOROSIS, OSTEOARTHRITIS AND MUSCULOSKELETAL DISEASES -WCO-IOF-ESCEO April 2-5, 2020 in Barcelona, Spain. The 20th Edition of the...
Do you have a research question that would help to achieve the objectives of GEMSTONE? But you do not have the tools to answer it in your lab? A grant for a Short Term Scientific Mission (STSM) might help you!
The first training school for Gemstone Cost Action 181389 will take place on 28 November 2019 in Malta.
The first Gemstone meeting will take place 27-29 of November in Malta.