COST Action CA18139

Genomics of MusculoSkeletal traits Translational Network

Join the Action

The Action is an open, interdisciplinary and growing network welcoming academics, practitioners and relevant stakeholders to contribute to the activities of the GEMSTONE.


The musculoskeletal system is a key element for healthy aging, being mobility a fundamental component of quality of life, health, and independence of aging individuals.
The unprecedented amount of discoveries arising from genome-wide association studies (GWAS) have set a new era full of translational potential in the field of musculoskeletal biology. Coupled to the growing understanding of monogenetic disorders, the GWAS discoveries have set a roadmap characterizing the biological pathways underlying the musculoskeletal metabolism. The musculoskeletal field is now confronted with new biology arising in the form of novel factors clustering in known molecular pathways but also with novel factors whose role and function remains to be elucidated.

Several opportunities to increase the amount of discoveries like the imminence of whole-genome sequencing efforts, the advent of a new generation of “very-low cost” GWAS arrays and the availability of very large mega GWAS studies like the UKBIOBANK are now in place. The challenge is now about bringing the knowledge arising from high-throughput analysis of increasingly available BIG DATA to a larger set of researchers, who can both contribute to 1) generating additional genetic discoveries and 2) setting the ground for their functional characterization in order to translate these genetic discoveries into meaningful clinical applications. To do this, GEMSTONE will be the mechanism to reach out to a wider range of researchers active in musculoskeletal biology, in order to fuel the production of discoveries and their biological relevance, which will allow their translation to treatments and new molecular definitions.

Latest News

4 postdoc positions to join the ERA-Net project IMMOSCAN and work on the role of immune osteoclasts in cancer – implications for therapy.
STSM and VNT call 2022 opens today. Application deadline: 2 October 2022 The applications will be evaluated by the Grant Awarding Coordinator and supported by the Grant Awarding Committee members....
Applications should be submitted at and should include a detailed CV with a complete list of publications and other relevant achievements.Place of Work: University of L’Aquila, Italy, Department of...

Upcoming Events

3 October
WG1-WG6 One-to-one meeting: second stage of data collection
This meeting will involve the WG1 leaders and the leaders of each of the other WGs Meeting agenda: -Describing the support WG1 can provide -Ask for detailed information about the...
Location: Virtual (Netherlands)
3 October
WG1 second semester meeting
This meeting will be held twice a year and will involve the WG1 members to coordinate the activities based on the information provided by the other WGs. Meeting agenda: -Summarise...
Location: Virtual (Netherlands)