The Training School “Gene regulation of the bone extracellular matrix” will be held in Porto (Portugal) from the 22nd to 24th of March 2022. The course will have the duration of three days, with lectures in the morning and lab sessions for students in the afternoon. It will focus on the genetic regulation of the bone extracellular matrix proteins, combining concepts of bioengineering and molecular biology. Topics such as cell differentiation, extracellular matrix remodeling, bone cells microenvironment, and GWAS studies will be addressed. This is an opportunity to potentiate new collaborations in an informal event. Participants are encouraged to bring questions that can contribute to the advance of knowledge through interactive approaches.