Events

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GEMSTONE WG4 TS: Osteoblast cell models and functional GWAS hits validation

GEMSTONE WG4 TS: Osteoblast cell models and functional GWAS hits validation

Event Details

Start Date: September 12, 2022
End Date: September 14, 2022
Venue:
Location: Ljubljana (Slovenia)

In vitro cell culturing and osteoblast cell models are an essential step in
functional validation of potential novel GWAS gene targets, as they allow
confirmation of genes’ involvement in bone related processes and the analysis
of underlying mechanisms on a cellular level, before we proceed with in vivo
experiments on animal models. This workshop will take its participants on the
journey from detection of novel gene candidates in GWA studies to functional
validation of these genes through osteoblast cell culturing, gene over- or under-
expression and techniques for validation of osteoblast function and
determination of functional roles of the studied genes. The participants will learn
to culture and differentiate osteoblast cell lines and design in vitro experiments
and analyse osteoblast function through measurement of mineralization. All
“YRI” (Young Researcher and Innovator) of the network will be invited. If the
number of applying trainees exceeds 15, a selection based on CV will be made.
The selected trainees will be prioritized as follows: 1. Affiliation in ITC 2.Career
stage (the earlier career stage will be prioritized) 3. WG membership 4. Sex
balanc