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Publication WG: WG4

Sugar transporter Slc37a2 regulates bonemetabolism in mice via a tubular lysosomalnetwork in osteoclasts
Pei Ying Ng # 1, Amy B P Ribet # 1, Qiang Guo # 1 2, Benjamin H Mullin 1 3, Jamie W Y Tan 1, Euphemie Landao-Bassonga 1, Sébastien Stephens 4, Kai Chen 1, Jinbo Yuan 1, Laila Abudulai 1 5 6, Maike Bollen 5 6, Edward T T T Nguyen 1, Jasreen Kular 1, John M Papadimitriou 7, Kent Søe 8 9, Rohan D Teasdale 10, Jiake Xu 1, Robert G...
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A variability in response of osteoclasts to zoledronic acid is mediated by smoking associated modifcation in the DNA methylome
Qihua Tan, Anaïs Marie Julie Møller, Chuan Qiu, Jonna Skov Madsen, Hui Shen, Troels Bechmann, Jean-Marie Delaisse, Bjarne Winther Kristensen, Hong-Wen Deng, David Karasik & Kent Søe A variability in response of osteoclasts to zoledronic acid is mediated by smoking-associated modification...
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The genetic overlap between osteoporosis and craniosynostosis
Erika Kague1*, Carolina Medina-Gomez2, Simeon A. Boyadjiev3 and Fernando Rivadeneira4 Published Sep 2022 https://doi.org/10.3389/fendo.2022.1020821 Osteoporosis is the most prevalent bone condition in the ageing population. This systemic disease is characterized by microarchitectural deterioration of...
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Zoledronic Acid Is Not Equally Potent on Osteoclasts Generated From Different Individuals
Anaïs M J Møller, Jean-Marie Delaisse, Jacob B Olesen, Troels Bechmann, Jonna S Madsen, Kent Søe First published: 15 September 2020DOI: https://doi.org/10.1002/jbm4.10412 Zoledronic acid is a bisphosphonate commonly used to treat...
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Deletion of SREBF1, a Functional Bone-Muscle Pleiotropic Gene, Alters Bone Density and Lipid Signaling in Zebrafish
Chen Shochat, Zhiying Wang, Chenglin Mo, Sarah Nelson, Rajashekar Donaka, Jian Huang, David Karasik, Marco BrottoEndocrinology, Volume 162, Issue 1, January 2021, bqaa189, https://doi.org/10.1210/endocr/bqaa189Published: 17 October 2020 Through a genome-wide analysis of bone mineral density (BMD) and muscle mass,...
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COST Action CA18139

The musculoskeletal system is a key element for healthy aging, being mobility a fundamental component of quality of life, health, and independence of aging individuals. The unprecedented amount of discoveries arising from  genome-wide association studies (GWAS) have set a new era full of translational potential in the field of musculoskeletal biology.

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